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In the analysis, published in the February 2026 issue of Clinical Obesity , researchers reviewed six studies involving 480,825 adults with diabetes, obesity, or both who were taking GLP-1 drugs

Based on this, we studied whether the metabolic switch from mitochondrial OXPHOS to cytosolic aerobic glycolysis is required and/or sufficient for the immune activation seen in UQCR-C1 (and other OXPHOS complex) knockdown hemocytes

These cell types are also impacted by G6PD and PPP activity with respect to ROS homeostasis and biosynthesis of effector molecules, and this can impact their downstream contribution to systemic inflammation